TGFB1I1

Gene Information

Official Symbol: TGFB1I1
Official Name: transforming growth factor beta 1 induced transcript 1
Aliases and Previous Symbols: N/A
Entrez ID: 7041
UniProt: O43294
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA- binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8209
Expression level (log2 read counts): 1.69

Expression Distribution

Paxillin
LIM

ubiquitin-dependent SMAD protein catabolic process
Roundabout binding
I-SMAD binding
positive regulation of cellular response to transforming growth factor beta stimulus
positive regulation of transforming growth factor beta receptor signaling pathway
androgen receptor signaling pathway
androgen receptor binding
negative regulation of fat cell differentiation
positive regulation of epithelial to mesenchymal transition
intracellular steroid hormone receptor signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of cellular response to transforming growth factor beta stimulus
transcription coregulator activity
regulation of epithelial to mesenchymal transition
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
response to heat
nuclear matrix
regulation of transforming growth factor beta receptor signaling pathway
regulation of cellular response to transforming growth factor beta stimulus
negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
steroid hormone mediated signaling pathway
regulation of fat cell differentiation
morphogenesis of embryonic epithelium
negative regulation of cellular response to growth factor stimulus
intracellular receptor signaling pathway
hormone-mediated signaling pathway
response to temperature stimulus
cellular response to steroid hormone stimulus
transmembrane receptor protein serine/threonine kinase signaling pathway
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
cell fate commitment
regulation of cellular response to growth factor stimulus
transcription coactivator activity
response to steroid hormone
cell-cell signaling by wnt
Wnt signaling pathway
collagen-containing extracellular matrix
cytoskeleton
focal adhesion
cell surface receptor signaling pathway involved in cell-cell signaling