THAP11 [The Human Chemical-Genetic Interaction Map Project]

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======= THAP11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: THAP11
  * **<color #00a2e8>Official Name</color>**: THAP domain containing 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57215|57215]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EK4|Q96EK4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=THAP11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20THAP11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609119|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|THAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|intercellular bridge|
|DNA-binding transcription repressor activity, RNA polymerase II-specific|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|zinc ion binding|
|negative regulation of transcription by RNA polymerase II|
|negative regulation of transcription, DNA-templated|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.69|
|[[:results:exp497|Lead acetate 2000μM R08 exp497]]|-1.86|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|-1.83|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|-1.8|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.7|
|[[:results:exp426|FBS-Wisent 0.1 R07 exp426]]|1.74|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.09|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.34|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 113/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|7/28|
|bone|7/26|
|breast|6/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|5/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|2/21|
|liver|5/20|
|lung|11/75|
|lymphocyte|5/16|
|ovary|4/26|
|pancreas|2/24|
|peripheral nervous system|2/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|3/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|3/22|
|urinary tract|3/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1049
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.03 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='THAP11 Expression in NALM6 Cells: 5.03'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>