THAP11

Entrez Summary: N/A
UniProt Summary: Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 113/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	5/28
blood	7/28
bone	7/26
breast	6/33
central nervous system	2/56
cervix	0/4
colorectal	1/17
esophagus	5/13
fibroblast	0/1
gastric	1/16
kidney	2/21
liver	5/20
lung	11/75
lymphocyte	5/16
ovary	4/26
pancreas	2/24
peripheral nervous system	2/16
plasma cell	8/15
prostate	0/1
skin	3/24
soft tissue	1/9
thyroid	0/2
upper aerodigestive	3/22
urinary tract	3/29
uterus	0/5

Expression Distribution

intercellular bridge
DNA-binding transcription repressor activity, RNA polymerase II-specific
RNA polymerase II proximal promoter sequence-specific DNA binding
zinc ion binding
negative regulation of transcription by RNA polymerase II
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of gene expression