THTPA

Entrez Summary: N/A
UniProt Summary: Hydrolase highly specific for thiamine triphosphate (ThTP). {ECO:0000269|PubMed:11827967, ECO:0000269|PubMed:23707715}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

thiamin-triphosphatase activity
thiamine diphosphate metabolic process
thiamine metabolic process
thiamine-containing compound metabolic process
hydrolase activity
water-soluble vitamin metabolic process
pyrimidine-containing compound metabolic process
vitamin metabolic process
magnesium ion binding
coenzyme metabolic process
dephosphorylation
sulfur compound metabolic process
generation of precursor metabolites and energy
cofactor metabolic process
drug metabolic process
organophosphate metabolic process
small molecule metabolic process