TIMP2
Gene Information
- Official Symbol: TIMP2
- Official Name: TIMP metallopeptidase inhibitor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 7077
- UniProt: P16035
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. {ECO:0000269|PubMed:11710594, ECO:0000269|PubMed:2554304, ECO:0000269|PubMed:2793861}.
Pfam Domains GO Terms
Pfam Domains
| TIMP |
GO Terms
| regulation of Rap protein signal transduction |
| negative regulation of metallopeptidase activity |
| negative regulation of membrane protein ectodomain proteolysis |
| positive regulation of adenylate cyclase activity |
| regulation of metallopeptidase activity |
| peptidase inhibitor activity |
| metalloendopeptidase inhibitor activity |
| positive regulation of cyclase activity |
| regulation of membrane protein ectodomain proteolysis |
| positive regulation of lyase activity |
| regulation of adenylate cyclase activity |
| regulation of cyclase activity |
| regulation of lyase activity |
| negative regulation of Ras protein signal transduction |
| tertiary granule lumen |
| negative regulation of small GTPase mediated signal transduction |
| specific granule lumen |
| extracellular matrix disassembly |
| protease binding |
| ficolin-1-rich granule lumen |
| growth cone |
| integrin binding |
| negative regulation of protein catabolic process |
| extracellular matrix |
| regulation of Ras protein signal transduction |
| negative regulation of endopeptidase activity |
| negative regulation of cellular catabolic process |
| negative regulation of peptidase activity |
| aging |
| negative regulation of mitotic cell cycle |
| negative regulation of catabolic process |
| extracellular matrix organization |
| regulation of small GTPase mediated signal transduction |
| negative regulation of proteolysis |
| collagen-containing extracellular matrix |
| positive regulation of neuron differentiation |
| neuronal cell body |
| regulation of protein catabolic process |
| extracellular structure organization |
| cellular component disassembly |
| regulation of endopeptidase activity |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| positive regulation of neurogenesis |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| negative regulation of intracellular signal transduction |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| positive regulation of nervous system development |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| negative regulation of cell cycle |
| myeloid leukocyte activation |
| cell surface |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of mitotic cell cycle |
| regulation of neuron differentiation |
| negative regulation of cell population proliferation |
| regulated exocytosis |
| regulation of proteolysis |
| regulation of MAPK cascade |
| leukocyte mediated immunity |
| negative regulation of catalytic activity |
| exocytosis |
| regulation of neurogenesis |
| regulation of cellular catabolic process |
| zinc ion binding |
| response to hormone |
| regulation of nervous system development |
| leukocyte activation |
| regulation of cell development |
| positive regulation of cell differentiation |
| central nervous system development |
| regulation of catabolic process |
| secretion by cell |
| positive regulation of protein phosphorylation |
| response to drug |
| positive regulation of intracellular signal transduction |
| negative regulation of cellular protein metabolic process |
| export from cell |
| positive regulation of phosphorylation |
| cell activation |
| immune effector process |
| response to cytokine |
| negative regulation of protein metabolic process |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| regulation of cell cycle |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| generation of neurons |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13554
- Expression level (log2 read counts): 5.55
Expression Distribution
TIMP2 Expression in NALM6 Cells: 5.55
