TJP2

Entrez Summary: This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutations in this gene have been identified in patients with hypercholanemia, and genomic duplication of a 270 kb region including this gene causes autosomal dominant deafness-51. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

guanylate kinase activity
GDP metabolic process
establishment of endothelial intestinal barrier
GMP metabolic process
hippo signaling
establishment of endothelial barrier
intestinal absorption
purine ribonucleoside monophosphate metabolic process
purine nucleoside monophosphate metabolic process
guanosine-containing compound metabolic process
endothelial cell development
ribonucleoside monophosphate metabolic process
purine ribonucleoside metabolic process
purine nucleoside diphosphate metabolic process
purine ribonucleoside diphosphate metabolic process
adherens junction
purine nucleoside metabolic process
ribonucleoside diphosphate metabolic process
nucleoside monophosphate metabolic process
digestive system process
ribonucleoside metabolic process
protein binding, bridging
regulation of membrane permeability
nucleoside diphosphate metabolic process
endothelial cell differentiation
endothelium development
nucleoside metabolic process
digestion
bicellular tight junction
glycosyl compound metabolic process
epithelial cell development
protein domain specific binding
cadherin binding
purine ribonucleotide metabolic process
ribonucleotide metabolic process
purine nucleotide metabolic process
ribose phosphate metabolic process
purine-containing compound metabolic process
nucleotide metabolic process
nucleoside phosphate metabolic process