TLL2

Entrez Summary: N/A
UniProt Summary: Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of skeletal muscle tissue growth
regulation of skeletal muscle tissue growth
negative regulation of skeletal muscle tissue development
negative regulation of striated muscle tissue development
regulation of skeletal muscle tissue development
negative regulation of muscle organ development
negative regulation of muscle tissue development
extracellular matrix disassembly
metalloendopeptidase activity
negative regulation of developmental growth
regulation of striated muscle tissue development
regulation of muscle tissue development
regulation of muscle organ development
negative regulation of growth
regulation of developmental growth
extracellular matrix organization
extracellular structure organization
cellular component disassembly
regulation of growth
calcium ion binding
zinc ion binding
negative regulation of developmental process
negative regulation of multicellular organismal process
proteolysis
extracellular region