TM7SF3

Entrez Summary: N/A
UniProt Summary: Involved in the inhibition of cytokine-induced death of pancreatic beta cells. Involved in the promotion of insulin secretion from pancreatic beta cells (PubMed:21853325). Is a downstream transcriptional target of p53/TP53, and acts as a pro- survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (PubMed:27740623). {ECO:0000269|PubMed:21853325, ECO:0000269|PubMed:27740623}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

positive regulation of insulin secretion
positive regulation of peptide hormone secretion
cellular response to unfolded protein
positive regulation of hormone secretion
cellular response to topologically incorrect protein
response to unfolded protein
regulation of insulin secretion
response to topologically incorrect protein
regulation of peptide hormone secretion
regulation of hormone secretion
positive regulation of protein secretion
positive regulation of peptide secretion
positive regulation of secretion by cell
positive regulation of protein transport
positive regulation of secretion
positive regulation of establishment of protein localization
regulation of protein secretion
regulation of peptide secretion
regulation of hormone levels
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
molecular function
regulation of secretion
negative regulation of programmed cell death
positive regulation of transport
negative regulation of cell death
regulation of protein localization
regulation of programmed cell death
regulation of cell death
cellular response to stress
positive regulation of cell communication
positive regulation of signaling
regulation of transport