TMA16 [The Human Chemical-Genetic Interaction Map Project]

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======= TMA16 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMA16
  * **<color #00a2e8>Official Name</color>**: translation machinery associated 16 homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55319|55319]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96EY4|Q96EY4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMA16&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMA16|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2962|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleolus|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.99|
|[[:results:exp490|Hydroxychloroquine 30μM R08 exp490]]|-1.97|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.96|
|[[:results:exp61|YM155 0.0002μM R01 exp61]]|-1.91|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.89|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-1.86|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|-1.86|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.82|
|[[:results:exp455|Benzoate 10000μM R08 exp455]]|-1.72|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.71|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.89|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.14|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.537|
|[[:human genes:c:chchd4|CHCHD4]]|0.45|
|[[:human genes:h:haus8|HAUS8]]|0.448|
|[[:human genes:t:thg1l|THG1L]]|0.429|
|[[:human genes:a:alg13|ALG13]]|0.426|
|[[:human genes:d:ddx20|DDX20]]|0.425|
|[[:human genes:d:dhps|DHPS]]|0.406|
|[[:human genes:e:eftud1|EFTUD1]]|0.405|
|[[:human genes:t:ten1|TEN1]]|0.405|
|[[:human genes:v:vezt|VEZT]]|0.404|
|[[:human genes:s:srp14|SRP14]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 490/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|19/28|
|blood|8/28|
|bone|15/26|
|breast|17/33|
|central nervous system|45/56|
|cervix|3/4|
|colorectal|12/17|
|esophagus|10/13|
|fibroblast|1/1|
|gastric|12/16|
|kidney|17/21|
|liver|13/20|
|lung|51/75|
|lymphocyte|11/16|
|ovary|16/26|
|pancreas|18/24|
|peripheral nervous system|10/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|16/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|17/22|
|urinary tract|26/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8350
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.58 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMA16 Expression in NALM6 Cells: 5.58'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>