TMED9

Entrez Summary: This gene is a member of a family of genes encoding transport proteins located in the endoplasmic reticulum and the Golgi. A similar gene in mouse is the target of microRNA miR-296, which is part of an imprinted cluster. [provided by RefSeq, Jul 2016].
UniProt Summary: Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:14600267, ECO:0000269|PubMed:16595549, ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:19296914}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 2/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	1/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Golgicide-A 4μM R03 exp122	-2.04
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.71
Bortezomib 0.005μM R00 exp6	-1.71

COPI-coated vesicle budding
COPI coating of Golgi vesicle
Golgi transport vesicle coating
early endosome to Golgi transport
trans-Golgi network transport vesicle
protein exit from endoplasmic reticulum
COPII-coated ER to Golgi transport vesicle
syntaxin binding
vesicle coating
endoplasmic reticulum-Golgi intermediate compartment membrane
vesicle targeting, to, from or within Golgi
endoplasmic reticulum-Golgi intermediate compartment
Golgi vesicle budding
retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
vesicle targeting
transport vesicle
retrograde transport, endosome to Golgi
vesicle budding from membrane
synaptic vesicle
Golgi organization
cytosolic transport
establishment of vesicle localization
vesicle localization
endoplasmic reticulum to Golgi vesicle-mediated transport
endosomal transport
vesicle organization
establishment of organelle localization
Golgi vesicle transport
endomembrane system organization
organelle localization
Golgi membrane
positive regulation of organelle organization
membrane organization
endoplasmic reticulum membrane
Golgi apparatus
intracellular protein transport
endoplasmic reticulum
positive regulation of cellular component organization
regulation of organelle organization
protein transport