TMEM161B [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM161B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM161B
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 161B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=153396|153396]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NDZ6|Q8NDZ6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM161B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM161B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/621178|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='default' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|rve|
|Tmemb 161AB|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
No GO term information is available for this gene.
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-2.53|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.13|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-2.06|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.74|
|[[:results:exp77|Prochlorperazine 5.2μM R02 exp77]]|1.72|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.86|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|1.97|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|1.99|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.01|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.09|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.36|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.42|
|[[:results:exp45|Docetaxel 0.002μM R01 exp45]]|2.53|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|2.58|
|[[:results:exp59|UMK57 1μM R01 exp59]]|2.67|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.75|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|3.8|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|4.41|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|4.54|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|6.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:a:atp1a1|ATP1A1]]|0.772|
|[[:human genes:p:pigf|PIGF]]|0.609|
|[[:human genes:p:pigo|PIGO]]|0.592|
|[[:human genes:a:atat1|ATAT1]]|0.577|
|[[:human genes:a:atp1b3|ATP1B3]]|0.518|
|[[:human genes:n:ndrg3|NDRG3]]|0.502|
|[[:human genes:p:prkar1a|PRKAR1A]]|0.472|
|[[:human genes:a:ahcyl1|AHCYL1]]|0.451|
|[[:human genes:t:tmx2|TMX2]]|0.447|
|[[:human genes:g:glmn|GLMN]]|0.433|
|[[:human genes:e:ehmt2|EHMT2]]|0.414|
|[[:human genes:f:fkbp5|FKBP5]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2321
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM161B Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>