TMEM175

Gene Information
  • Official Symbol: TMEM175
  • Official Name: transmembrane protein 175
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 84286
  • UniProt: Q9BSA9
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: N/A
  • UniProt Summary: Organelle-specific potassium channel specifically responsible for potassium conductance in endosomes and lysosomes. Forms a potassium-permeable leak-like channel, which regulates lumenal pH stability and is required for autophagosome-lysosome fusion. Constitutes the major lysosomal potassium channel. {ECO:0000269|PubMed:26317472, ECO:0000269|PubMed:28723891}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 16031
  • Expression level (log2 read counts): 4.43

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1