TMEM201

Entrez Summary: N/A
UniProt Summary: Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin- dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (PubMed:27541860). {ECO:0000250|UniProtKB:A2A8U2, ECO:0000305|PubMed:27541860}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

DUF2448
DUF2349

nuclear migration along microtubule
fibroblast migration
integral component of nuclear inner membrane
lamin binding
nuclear migration
nucleus localization
organelle transport along microtubule
spindle pole
transport along microtubule
ameboidal-type cell migration
cytoskeleton-dependent intracellular transport
microtubule-based transport
actin filament binding
nuclear membrane
microtubule-based movement
establishment of organelle localization
organelle localization
microtubule-based process
cell migration
cell motility
localization of cell
locomotion
intracellular transport
movement of cell or subcellular component
establishment of localization in cell