TMEM258 [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM258 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM258
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 258
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=746|746]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61165|P61165]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM258&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM258|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617615|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for full OST catalytic activity in N-glycosylation (PubMed:26472760, PubMed:27974209). Involved in endoplasmic reticulum (ER) homeostasis in the colonic epithelium (By similarity). {ECO:0000250|UniProtKB:P61166, ECO:0000269|PubMed:26472760, ECO:0000269|PubMed:27974209}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UPF0197|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|oligosaccharyltransferase I complex|
|protein N-linked glycosylation|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|glycoprotein biosynthetic process|
|glycoprotein metabolic process|
|carbohydrate derivative biosynthetic process|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|organonitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|1.7|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|1.79|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|1.85|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.86|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|1.89|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rpn1|RPN1]]|0.477|
|[[:human genes:d:ddost|DDOST]]|0.461|
|[[:human genes:o:ost4|OST4]]|0.419|
|[[:human genes:r:rpn2|RPN2]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 288/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|12/28|
|blood|9/28|
|bone|7/26|
|breast|4/33|
|central nervous system|25/56|
|cervix|2/4|
|colorectal|6/17|
|esophagus|3/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|14/21|
|liver|12/20|
|lung|32/75|
|lymphocyte|6/16|
|ovary|14/26|
|pancreas|11/24|
|peripheral nervous system|5/16|
|plasma cell|4/15|
|prostate|1/1|
|skin|10/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|9/22|
|urinary tract|9/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1056
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.01 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM258 Expression in NALM6 Cells: 5.01'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>