TMEM258

Entrez Summary: N/A
UniProt Summary: Acts as component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for full OST catalytic activity in N-glycosylation (PubMed:26472760, PubMed:27974209). Involved in endoplasmic reticulum (ER) homeostasis in the colonic epithelium (By similarity). {ECO:0000250|UniProtKB:P61166, ECO:0000269|PubMed:26472760, ECO:0000269|PubMed:27974209}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 288/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	12/28
blood	9/28
bone	7/26
breast	4/33
central nervous system	25/56
cervix	2/4
colorectal	6/17
esophagus	3/13
fibroblast	0/1
gastric	7/16
kidney	14/21
liver	12/20
lung	32/75
lymphocyte	6/16
ovary	14/26
pancreas	11/24
peripheral nervous system	5/16
plasma cell	4/15
prostate	1/1
skin	10/24
soft tissue	4/9
thyroid	1/2
upper aerodigestive	9/22
urinary tract	9/29
uterus	4/5

Expression Distribution

oligosaccharyltransferase I complex
protein N-linked glycosylation
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate derivative biosynthetic process
endoplasmic reticulum
carbohydrate derivative metabolic process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process