TMEM59 [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM59 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM59
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 59
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9528|9528]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BXS4|Q9BXS4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM59&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM59|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617084|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278). {ECO:0000269|PubMed:20427278, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BSMAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of protein glycosylation in Golgi|
|regulation of protein glycosylation in Golgi|
|negative regulation of protein glycosylation|
|Golgi trans cisterna|
|Golgi medial cisterna|
|negative regulation of glycoprotein biosynthetic process|
|regulation of protein glycosylation|
|negative regulation of glycoprotein metabolic process|
|negative regulation of protein localization to plasma membrane|
|negative regulation of protein localization to cell periphery|
|Golgi cis cisterna|
|negative regulation of protein localization to membrane|
|negative regulation of protein processing|
|negative regulation of protein maturation|
|regulation of glycoprotein biosynthetic process|
|regulation of glycoprotein metabolic process|
|regulation of protein processing|
|regulation of protein maturation|
|endopeptidase activity|
|regulation of protein localization to plasma membrane|
|negative regulation of cellular protein localization|
|regulation of protein localization to cell periphery|
|late endosome membrane|
|positive regulation of autophagy|
|late endosome|
|regulation of protein localization to membrane|
|lysosome|
|process utilizing autophagic mechanism|
|autophagy|
|lysosomal membrane|
|regulation of autophagy|
|negative regulation of proteolysis|
|positive regulation of cellular catabolic process|
|positive regulation of catabolic process|
|regulation of cellular protein localization|
|negative regulation of protein modification process|
|Golgi membrane|
|regulation of proteolysis|
|regulation of cellular catabolic process|
|regulation of cellular localization|
|regulation of catabolic process|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|negative regulation of protein metabolic process|
|proteolysis|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|negative regulation of gene expression|
|cellular catabolic process|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|-1.93|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9331
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM59 Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>