TMEM59

Entrez Summary: N/A
UniProt Summary: Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:27273576, PubMed:23376921). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278). {ECO:0000269|PubMed:20427278, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
KU-0063794 3.8μM R02 exp71	-1.93
NFN1 0.1μM R01 exp49	-1.8

negative regulation of protein glycosylation in Golgi
regulation of protein glycosylation in Golgi
negative regulation of protein glycosylation
Golgi trans cisterna
Golgi medial cisterna
negative regulation of glycoprotein biosynthetic process
regulation of protein glycosylation
negative regulation of glycoprotein metabolic process
negative regulation of protein localization to plasma membrane
negative regulation of protein localization to cell periphery
Golgi cis cisterna
negative regulation of protein localization to membrane
negative regulation of protein processing
negative regulation of protein maturation
regulation of glycoprotein biosynthetic process
regulation of glycoprotein metabolic process
regulation of protein processing
regulation of protein maturation
endopeptidase activity
regulation of protein localization to plasma membrane
negative regulation of cellular protein localization
regulation of protein localization to cell periphery
late endosome membrane
positive regulation of autophagy
late endosome
regulation of protein localization to membrane
lysosome
process utilizing autophagic mechanism
autophagy
lysosomal membrane
regulation of autophagy
negative regulation of proteolysis
positive regulation of cellular catabolic process
positive regulation of catabolic process
regulation of cellular protein localization
negative regulation of protein modification process
Golgi membrane
regulation of proteolysis
regulation of cellular catabolic process
regulation of cellular localization