TMEM98 [The Human Chemical-Genetic Interaction Map Project]

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======= TMEM98 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TMEM98
  * **<color #00a2e8>Official Name</color>**: transmembrane protein 98
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=26022|26022]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y2Y6|Q9Y2Y6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TMEM98&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TMEM98|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615949|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of myelination|
|T-helper 1 cell differentiation|
|negative regulation of oligodendrocyte differentiation|
|T-helper 1 type immune response|
|negative regulation of glial cell differentiation|
|negative regulation of nervous system process|
|T-helper cell differentiation|
|CD4-positive, alpha-beta T cell differentiation involved in immune response|
|alpha-beta T cell differentiation involved in immune response|
|alpha-beta T cell activation involved in immune response|
|negative regulation of protein localization to nucleus|
|T cell differentiation involved in immune response|
|negative regulation of protein processing|
|negative regulation of protein maturation|
|CD4-positive, alpha-beta T cell differentiation|
|CD4-positive, alpha-beta T cell activation|
|regulation of oligodendrocyte differentiation|
|negative regulation of gliogenesis|
|regulation of myelination|
|alpha-beta T cell differentiation|
|alpha-beta T cell activation|
|T cell activation involved in immune response|
|regulation of protein processing|
|regulation of protein maturation|
|regulation of glial cell differentiation|
|lymphocyte activation involved in immune response|
|negative regulation of cellular protein localization|
|regulation of gliogenesis|
|regulation of protein localization to nucleus|
|T cell differentiation|
|regulation of nervous system process|
|T cell activation|
|lymphocyte differentiation|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|negative regulation of neurogenesis|
|negative regulation of nervous system development|
|leukocyte differentiation|
|negative regulation of cell development|
|negative regulation of proteolysis|
|lymphocyte activation|
|regulation of cellular protein localization|
|hemopoiesis|
|regulation of system process|
|hematopoietic or lymphoid organ development|
|adaptive immune response|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|immune system development|
|negative regulation of cell differentiation|
|regulation of proteolysis|
|regulation of neurogenesis|
|regulation of cellular localization|
|regulation of nervous system development|
|leukocyte activation|
|regulation of cell development|
|endoplasmic reticulum membrane|
|negative regulation of developmental process|
|endoplasmic reticulum|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|cell activation|
|immune effector process|
|negative regulation of protein metabolic process|
|negative regulation of multicellular organismal process|
|generation of neurons|
|extracellular space|
|neurogenesis|
|negative regulation of gene expression|
|regulation of cell differentiation|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15445
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TMEM98 Expression in NALM6 Cells: 1.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>