TMEM98

Gene Information

Official Symbol: TMEM98
Official Name: transmembrane protein 98
Aliases and Previous Symbols: N/A
Entrez ID: 26022
UniProt: Q9Y2Y6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a transmembrane protein. A missense mutation in this gene result in Nanophthalmos 4 (NNO4). Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2014].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15445
Expression level (log2 read counts): 1.65

Expression Distribution

negative regulation of myelination
T-helper 1 cell differentiation
negative regulation of oligodendrocyte differentiation
T-helper 1 type immune response
negative regulation of glial cell differentiation
negative regulation of nervous system process
T-helper cell differentiation
CD4-positive, alpha-beta T cell differentiation involved in immune response
alpha-beta T cell differentiation involved in immune response
alpha-beta T cell activation involved in immune response
negative regulation of protein localization to nucleus
T cell differentiation involved in immune response
negative regulation of protein processing
negative regulation of protein maturation
CD4-positive, alpha-beta T cell differentiation
CD4-positive, alpha-beta T cell activation
regulation of oligodendrocyte differentiation
negative regulation of gliogenesis
regulation of myelination
alpha-beta T cell differentiation
alpha-beta T cell activation
T cell activation involved in immune response
regulation of protein processing
regulation of protein maturation
regulation of glial cell differentiation
lymphocyte activation involved in immune response
negative regulation of cellular protein localization
regulation of gliogenesis
regulation of protein localization to nucleus
T cell differentiation
regulation of nervous system process
T cell activation
lymphocyte differentiation
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
negative regulation of neurogenesis
negative regulation of nervous system development
leukocyte differentiation
negative regulation of cell development
negative regulation of proteolysis
lymphocyte activation