TMOD1

Entrez Summary: N/A
UniProt Summary: Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. {ECO:0000269|PubMed:8002995}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

pointed-end actin filament capping
lens fiber cell development
tropomyosin binding
striated muscle thin filament
cortical cytoskeleton
lens fiber cell differentiation
myofibril
actin filament capping
negative regulation of actin filament depolymerization
COP9 signalosome
muscle filament sliding
actin-myosin filament sliding
sarcomere
regulation of actin filament depolymerization
negative regulation of actin filament polymerization
negative regulation of protein depolymerization
negative regulation of protein polymerization
myofibril assembly
negative regulation of protein complex disassembly
lens development in camera-type eye
adult locomotory behavior
actin filament
regulation of protein depolymerization
actin-mediated cell contraction
cellular component assembly involved in morphogenesis
actin filament-based movement
regulation of protein complex disassembly
actomyosin structure organization
negative regulation of supramolecular fiber organization
negative regulation of protein complex assembly
striated muscle cell development
negative regulation of cytoskeleton organization
adult behavior
muscle cell development
regulation of actin filament polymerization
regulation of actin polymerization or depolymerization
regulation of actin filament length
epithelial cell development
locomotory behavior
striated muscle cell differentiation