TMPRSS15
Gene Information
- Official Symbol: TMPRSS15
- Official Name: transmembrane serine protease 15
- Aliases and Previous Symbols: N/A
- Entrez ID: 5651
- UniProt: P98073
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008].
- UniProt Summary: Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 8674
- Expression level (log2 read counts): -4.27
TMPRSS15 Expression in NALM6 Cells: -4.27
