TNFAIP1

Entrez Summary: N/A
UniProt Summary: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. {ECO:0000269|PubMed:19637314, ECO:0000269|PubMed:19782033}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

stress fiber assembly
contractile actin filament bundle assembly
GTP-Rho binding
negative regulation of Rho protein signal transduction
positive regulation of DNA replication
Cul3-RING ubiquitin ligase complex
negative regulation of Ras protein signal transduction
negative regulation of small GTPase mediated signal transduction
actin filament bundle assembly
actin filament bundle organization
regulation of DNA replication
actomyosin structure organization
regulation of Rho protein signal transduction
DNA replication
actin filament organization
regulation of Ras protein signal transduction
protein domain specific binding
ubiquitin-protein transferase activity
endosome
proteasome-mediated ubiquitin-dependent protein catabolic process
protein homooligomerization
regulation of small GTPase mediated signal transduction
proteasomal protein catabolic process
supramolecular fiber organization
actin cytoskeleton organization
negative regulation of intracellular signal transduction
protein complex oligomerization
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
actin filament-based process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
protein ubiquitination
protein modification by small protein conjugation
nucleolus
cellular macromolecule catabolic process
apoptotic process
cell migration