TNFAIP8L2

Entrez Summary: N/A
UniProt Summary: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of T cell activation
negative regulation of leukocyte cell-cell adhesion
negative regulation of inflammatory response
negative regulation of lymphocyte activation
negative regulation of leukocyte activation
negative regulation of cell-cell adhesion
negative regulation of cell activation
negative regulation of defense response
negative regulation of cell adhesion
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
regulation of inflammatory response
negative regulation of response to external stimulus
regulation of cell-cell adhesion
negative regulation of immune system process
regulation of lymphocyte activation
regulation of leukocyte activation
regulation of cell activation
regulation of cell adhesion
regulation of defense response
innate immune response
defense response to other organism
regulation of response to external stimulus
response to other organism
response to external biotic stimulus
response to biotic stimulus
defense response
regulation of response to stress
regulation of apoptotic process
regulation of programmed cell death
negative regulation of response to stimulus
regulation of immune system process
regulation of cell death
immune response