TNFAIP8L3

Entrez Summary: N/A
UniProt Summary: Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling. {ECO:0000250|UniProtKB:Q3TBL6}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

phosphatidylinositol transfer activity
positive regulation of phosphatidylinositol 3-kinase activity
positive regulation of lipid kinase activity
positive regulation of phospholipid metabolic process
regulation of phosphatidylinositol 3-kinase activity
regulation of lipid kinase activity
inositol lipid-mediated signaling
regulation of phospholipid metabolic process
phosphatidylinositol binding
phospholipid transport
organophosphate ester transport
positive regulation of lipid metabolic process
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
regulation of protein kinase B signaling
regulation of ERK1 and ERK2 cascade
lipid transport
lipid localization
phospholipid metabolic process
regulation of lipid metabolic process
organic anion transport
positive regulation of MAPK cascade
positive regulation of kinase activity
anion transport
positive regulation of transferase activity
regulation of MAPK cascade
regulation of kinase activity
organophosphate metabolic process
cellular lipid metabolic process
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
positive regulation of phosphorylation
positive regulation of phosphate metabolic process
positive regulation of phosphorus metabolic process
lipid metabolic process
positive regulation of protein modification process
ion transport
positive regulation of catalytic activity
regulation of protein phosphorylation