TNFRSF10A

Gene Information

Official Symbol: TNFRSF10A
Official Name: TNF receptor superfamily member 10a
Aliases and Previous Symbols: N/A
Entrez ID: 8797
UniProt: O00220
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. {ECO:0000269|PubMed:26457518, ECO:0000269|PubMed:9430227}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 11735
Expression level (log2 read counts): 1.49

Expression Distribution

Gene	Correlation
POLR2J3	0.461
HGC6.3	0.444

Death
TNFR c6

death receptor activity
TRAIL binding
TRAIL-activated apoptotic signaling pathway
activation of NF-kappaB-inducing kinase activity
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of NIK/NF-kappaB signaling
cellular response to mechanical stimulus
NIK/NF-kappaB signaling
activation of cysteine-type endopeptidase activity involved in apoptotic process
extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
protease binding
regulation of NIK/NF-kappaB signaling
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of cysteine-type endopeptidase activity
regulation of extrinsic apoptotic signaling pathway
positive regulation of endopeptidase activity
positive regulation of peptidase activity
signaling receptor activity
response to mechanical stimulus
regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of apoptotic signaling pathway
regulation of cysteine-type endopeptidase activity
apoptotic signaling pathway
cellular response to abiotic stimulus
cellular response to environmental stimulus
activation of protein kinase activity
transcription factor binding
cellular response to external stimulus
positive regulation of proteolysis
leukocyte migration
regulation of apoptotic signaling pathway
regulation of endopeptidase activity
regulation of peptidase activity
positive regulation of protein kinase activity
positive regulation of kinase activity
cell surface
positive regulation of apoptotic process