TNFRSF12A

Entrez Summary: N/A
UniProt Summary: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins. {ECO:0000269|PubMed:11728344}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

substrate-dependent cell migration, cell attachment to substrate
substrate-dependent cell migration
positive regulation of axon extension
positive regulation of extrinsic apoptotic signaling pathway
positive regulation of axonogenesis
ruffle
regulation of axon extension
extrinsic apoptotic signaling pathway
regulation of extent of cell growth
tumor necrosis factor-mediated signaling pathway
regulation of wound healing
regulation of extrinsic apoptotic signaling pathway
positive regulation of cell morphogenesis involved in differentiation
positive regulation of cell growth
regulation of response to wounding
positive regulation of developmental growth
positive regulation of apoptotic signaling pathway
regulation of cell size
regulation of axonogenesis
cell-substrate adhesion
cellular response to tumor necrosis factor
positive regulation of growth
response to tumor necrosis factor
positive regulation of neuron projection development
apoptotic signaling pathway
regulation of angiogenesis
regulation of cell morphogenesis involved in differentiation
angiogenesis
regulation of vasculature development
regulation of developmental growth
positive regulation of neuron differentiation
regulation of cellular component size
positive regulation of cell projection organization
regulation of apoptotic signaling pathway
blood vessel morphogenesis
regulation of cell growth
positive regulation of neurogenesis
blood vessel development
regulation of cell morphogenesis
regulation of neuron projection development