TNFRSF18

Gene Information

Official Symbol: TNFRSF18
Official Name: TNF receptor superfamily member 18
Aliases and Previous Symbols: N/A
Entrez ID: 8784
UniProt: Q9Y5U5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8056
Expression level (log2 read counts): -7.68

Expression Distribution

tumor necrosis factor-activated receptor activity
regulation of regulatory T cell differentiation
positive regulation of tyrosine phosphorylation of STAT protein
regulation of tyrosine phosphorylation of STAT protein
positive regulation of receptor signaling pathway via JAK-STAT
positive regulation of receptor signaling pathway via STAT
tumor necrosis factor-mediated signaling pathway
positive regulation of leukocyte migration
regulation of receptor signaling pathway via JAK-STAT
regulation of receptor signaling pathway via STAT
regulation of T cell differentiation
regulation of lymphocyte differentiation
positive regulation of peptidyl-tyrosine phosphorylation
regulation of leukocyte migration
cellular response to tumor necrosis factor
regulation of peptidyl-tyrosine phosphorylation
response to tumor necrosis factor
regulation of leukocyte differentiation
regulation of T cell activation
positive regulation of cell adhesion
regulation of hemopoiesis
positive regulation of cell migration
regulation of lymphocyte activation
positive regulation of cell motility
positive regulation of cellular component movement
positive regulation of locomotion
regulation of leukocyte activation
regulation of cell activation
cytokine-mediated signaling pathway
regulation of cell adhesion
regulation of cell migration
negative regulation of apoptotic process
negative regulation of programmed cell death
regulation of cell motility
apoptotic process
regulation of locomotion
negative regulation of cell death
regulation of cellular component movement
cellular response to cytokine stimulus
positive regulation of protein phosphorylation