TNFRSF8

Gene Information

Official Symbol: TNFRSF8
Official Name: TNF receptor superfamily member 8
Aliases and Previous Symbols: N/A
Entrez ID: 943
UniProt: P28908
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 6721
Expression level (log2 read counts): 1.19

Expression Distribution

regulation of TRAIL biosynthetic process
positive regulation of TRAIL biosynthetic process
positive regulation of TRAIL production
regulation of TRAIL production
positive regulation of tumor necrosis factor biosynthetic process
regulation of tumor necrosis factor biosynthetic process
positive regulation of cytokine biosynthetic process
cellular response to mechanical stimulus
positive regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor superfamily cytokine production
regulation of cytokine biosynthetic process
tumor necrosis factor-mediated signaling pathway
transmembrane signaling receptor activity
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production
response to mechanical stimulus
cellular response to tumor necrosis factor
response to tumor necrosis factor
cellular response to environmental stimulus
cellular response to abiotic stimulus
cellular response to external stimulus
positive regulation of cytokine production
positive regulation of apoptotic process
positive regulation of programmed cell death
cytokine-mediated signaling pathway
negative regulation of cell population proliferation
regulation of cytokine production
positive regulation of cell death
cellular response to cytokine stimulus
response to cytokine
response to abiotic stimulus
regulation of apoptotic process
regulation of programmed cell death
regulation of cell population proliferation
regulation of cell death
positive regulation of protein metabolic process
positive regulation of multicellular organismal process
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of biosynthetic process