TNFSF10 [The Human Chemical-Genetic Interaction Map Project]

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======= TNFSF10 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNFSF10
  * **<color #00a2e8>Official Name</color>**: TNF superfamily member 10
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8743|8743]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P50591|P50591]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNFSF10&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNFSF10|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603598|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. {ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:26457518}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TNF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TRAIL binding|
|positive regulation of release of cytochrome c from mitochondria|
|tumor necrosis factor receptor binding|
|negative regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|regulation of release of cytochrome c from mitochondria|
|positive regulation of extrinsic apoptotic signaling pathway|
|regulation of extrinsic apoptotic signaling pathway via death domain receptors|
|activation of cysteine-type endopeptidase activity involved in apoptotic process|
|negative regulation of extrinsic apoptotic signaling pathway|
|positive regulation of mitochondrion organization|
|positive regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|male gonad development|
|development of primary male sexual characteristics|
|positive regulation of cysteine-type endopeptidase activity|
|regulation of extrinsic apoptotic signaling pathway|
|male sex differentiation|
|positive regulation of endopeptidase activity|
|cytokine activity|
|positive regulation of apoptotic signaling pathway|
|regulation of mitochondrion organization|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|positive regulation of peptidase activity|
|gonad development|
|regulation of cysteine-type endopeptidase activity involved in apoptotic process|
|development of primary sexual characteristics|
|negative regulation of apoptotic signaling pathway|
|response to insulin|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of cysteine-type endopeptidase activity|
|sex differentiation|
|signaling receptor binding|
|positive regulation of proteolysis|
|response to peptide hormone|
|regulation of apoptotic signaling pathway|
|regulation of endopeptidase activity|
|reproductive structure development|
|reproductive system development|
|regulation of peptidase activity|
|response to peptide|
|positive regulation of organelle organization|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|developmental process involved in reproduction|
|positive regulation of cell death|
|regulation of proteolysis|
|positive regulation of hydrolase activity|
|zinc ion binding|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|apoptotic process|
|negative regulation of cell death|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|programmed cell death|
|identical protein binding|
|response to nitrogen compound|
|cell death|
|cell-cell signaling|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|response to endogenous stimulus|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp446|4-Nitroquinoline-1-oxide 0.5μM R08 exp446]]|-1.8|
|[[:results:exp49|NFN1 0.1μM R01 exp49]]|-1.76|
|[[:results:exp302|35°C R06 exp302]]|1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|3/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18997
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNFSF10 Expression in NALM6 Cells: 0.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>