TNFSF10

Gene Information

Official Symbol: TNFSF10
Official Name: TNF superfamily member 10
Aliases and Previous Symbols: N/A
Entrez ID: 8743
UniProt: P50591
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. {ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:26457518}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 6/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	1/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	3/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18997
Expression level (log2 read counts): 0.68

Expression Distribution

Screen	Score
4-Nitroquinoline-1-oxide 0.5μM R08 exp446	-1.8
NFN1 0.1μM R01 exp49	-1.76
35°C R06 exp302	1.73

TRAIL binding
positive regulation of release of cytochrome c from mitochondria
tumor necrosis factor receptor binding
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of release of cytochrome c from mitochondria
positive regulation of extrinsic apoptotic signaling pathway
regulation of extrinsic apoptotic signaling pathway via death domain receptors
activation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of extrinsic apoptotic signaling pathway
positive regulation of mitochondrion organization
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
male gonad development
development of primary male sexual characteristics
positive regulation of cysteine-type endopeptidase activity
regulation of extrinsic apoptotic signaling pathway
male sex differentiation
positive regulation of endopeptidase activity
cytokine activity
positive regulation of apoptotic signaling pathway
regulation of mitochondrion organization
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of peptidase activity
gonad development
regulation of cysteine-type endopeptidase activity involved in apoptotic process
development of primary sexual characteristics
negative regulation of apoptotic signaling pathway
response to insulin
regulation of I-kappaB kinase/NF-kappaB signaling
regulation of cysteine-type endopeptidase activity
sex differentiation
signaling receptor binding
positive regulation of proteolysis
response to peptide hormone
regulation of apoptotic signaling pathway
regulation of endopeptidase activity
reproductive structure development
reproductive system development
regulation of peptidase activity
response to peptide
positive regulation of organelle organization