TNFSF9

Gene Information

Official Symbol: TNFSF9
Official Name: TNF superfamily member 9
Aliases and Previous Symbols: N/A
Entrez ID: 8744
UniProt: P41273
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. {ECO:0000269|PubMed:20032458}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15937
Expression level (log2 read counts): 1.81

Expression Distribution

positive regulation of cytotoxic T cell differentiation
regulation of cytotoxic T cell differentiation
tumor necrosis factor receptor superfamily binding
positive regulation of activated T cell proliferation
tumor necrosis factor receptor binding
regulation of activated T cell proliferation
positive regulation of T cell differentiation
positive regulation of lymphocyte differentiation
positive regulation of T cell proliferation
tumor necrosis factor-mediated signaling pathway
positive regulation of lymphocyte proliferation
positive regulation of mononuclear cell proliferation
positive regulation of leukocyte proliferation
regulation of T cell differentiation
positive regulation of leukocyte differentiation
regulation of T cell proliferation
regulation of lymphocyte differentiation
cytokine activity
positive regulation of hemopoiesis
positive regulation of T cell activation
regulation of lymphocyte proliferation
regulation of mononuclear cell proliferation
positive regulation of leukocyte cell-cell adhesion
regulation of leukocyte proliferation
cellular response to tumor necrosis factor
positive regulation of cell-cell adhesion
response to tumor necrosis factor
regulation of leukocyte differentiation
regulation of leukocyte cell-cell adhesion
regulation of T cell activation
signaling receptor binding
positive regulation of lymphocyte activation
regulation of cell-cell adhesion
positive regulation of leukocyte activation
positive regulation of cell adhesion
positive regulation of cell activation
regulation of hemopoiesis
regulation of lymphocyte activation
regulation of leukocyte activation
regulation of cell activation