TNMD [The Human Chemical-Genetic Interaction Map Project]

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======= TNMD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TNMD
  * **<color #00a2e8>Official Name</color>**: tenomodulin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64102|64102]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2S6|Q9H2S6]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TNMD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TNMD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300459|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  May be an angiogenesis inhibitor.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|BRICHOS|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tendon formation|
|tendon cell differentiation|
|tendon development|
|endothelial cell morphogenesis|
|negative regulation of vascular endothelial growth factor receptor signaling pathway|
|regulation of vascular endothelial growth factor receptor signaling pathway|
|epithelial cell morphogenesis|
|negative regulation of endothelial cell proliferation|
|endothelial cell development|
|endothelial cell differentiation|
|endothelium development|
|negative regulation of angiogenesis|
|cellular response to BMP stimulus|
|negative regulation of blood vessel morphogenesis|
|response to BMP|
|negative regulation of vasculature development|
|negative regulation of epithelial cell proliferation|
|regulation of endothelial cell proliferation|
|negative regulation of cellular response to growth factor stimulus|
|nuclear envelope|
|epithelial cell development|
|connective tissue development|
|regulation of cellular response to growth factor stimulus|
|regulation of angiogenesis|
|regulation of vasculature development|
|regulation of epithelial cell proliferation|
|cellular response to growth factor stimulus|
|response to growth factor|
|cell morphogenesis involved in differentiation|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|cell morphogenesis|
|cellular component morphogenesis|
|anatomical structure formation involved in morphogenesis|
|negative regulation of developmental process|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|negative regulation of multicellular organismal process|
|cellular response to endogenous stimulus|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|response to endogenous stimulus|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|cell development|
|tissue development|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 17956
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -7.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TNMD Expression in NALM6 Cells: -7.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>