TNMD

Gene Information

Official Symbol: TNMD
Official Name: tenomodulin
Aliases and Previous Symbols: N/A
Entrez ID: 64102
UniProt: Q9H2S6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a protein that is related to chondromodulin-I, which is a cartilage-specific glycoprotein that functions to stimulate chondrocyte growth and to inhibit tube formation of endothelial cells. This protein is also an angiogenesis inhibitor. Genetic variation in this gene is associated with a risk for type 2 diabetes, central obesity and serum levels of systemic immune mediators in a body size-dependent manner. This gene is also a candidate gene for age-related macular degeneration, though a direct link has yet to be demonstrated. [provided by RefSeq, Sep 2009].
UniProt Summary: May be an angiogenesis inhibitor.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17956
Expression level (log2 read counts): -7.68

Expression Distribution

tendon formation
tendon cell differentiation
tendon development
endothelial cell morphogenesis
negative regulation of vascular endothelial growth factor receptor signaling pathway
regulation of vascular endothelial growth factor receptor signaling pathway
epithelial cell morphogenesis
negative regulation of endothelial cell proliferation
endothelial cell development
endothelial cell differentiation
endothelium development
negative regulation of angiogenesis
cellular response to BMP stimulus
negative regulation of blood vessel morphogenesis
response to BMP
negative regulation of vasculature development
negative regulation of epithelial cell proliferation
regulation of endothelial cell proliferation
negative regulation of cellular response to growth factor stimulus
nuclear envelope
epithelial cell development
connective tissue development
regulation of cellular response to growth factor stimulus
regulation of angiogenesis
regulation of vasculature development
regulation of epithelial cell proliferation
cellular response to growth factor stimulus
response to growth factor
cell morphogenesis involved in differentiation
negative regulation of cell population proliferation
epithelial cell differentiation
cell morphogenesis
cellular component morphogenesis
anatomical structure formation involved in morphogenesis
negative regulation of developmental process
regulation of anatomical structure morphogenesis
epithelium development
negative regulation of multicellular organismal process
cellular response to endogenous stimulus
negative regulation of signal transduction