TNN
Gene Information
- Official Symbol: TNN
- Official Name: tenascin N
- Aliases and Previous Symbols: N/A
- Entrez ID: 63923
- UniProt: Q9UQP3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Fibrinogen C |
| fn3 |
GO Terms
| regulation of canonical Wnt signaling pathway involved in osteoblast differentiation |
| negative regulation of canonical Wnt signaling pathway involved in osteoblast differentiation |
| hippocampal mossy fiber expansion |
| CA3 pyramidal cell dendrite |
| negative regulation of osteoblast proliferation |
| negative regulation of neuron migration |
| dendrite self-avoidance |
| osteoblast development |
| regulation of osteoblast proliferation |
| regulation of neuron migration |
| negative regulation of osteoblast differentiation |
| neuron recognition |
| negative regulation of ossification |
| regulation of osteoblast differentiation |
| cell-matrix adhesion |
| osteoblast differentiation |
| integrin binding |
| negative regulation of canonical Wnt signaling pathway |
| cell-substrate adhesion |
| regulation of ossification |
| negative regulation of Wnt signaling pathway |
| extracellular matrix |
| cell recognition |
| negative regulation of cell migration |
| ossification |
| negative regulation of cell motility |
| regulation of canonical Wnt signaling pathway |
| negative regulation of neurogenesis |
| negative regulation of cellular component movement |
| negative regulation of nervous system development |
| negative regulation of locomotion |
| negative regulation of cell development |
| regulation of Wnt signaling pathway |
| neuronal cell body |
| axonogenesis |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| cellular component |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cell part morphogenesis |
| cell morphogenesis involved in differentiation |
| cell surface |
| neuron projection development |
| negative regulation of cell population proliferation |
| negative regulation of cell differentiation |
| cell morphogenesis |
| molecular function |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| regulation of cell migration |
| regulation of cell motility |
| regulation of nervous system development |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| regulation of locomotion |
| regulation of cellular component movement |
| neuron differentiation |
| identical protein binding |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| generation of neurons |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| ONC212 0.15μM R08 exp513 | -1.7 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4232
- Expression level (log2 read counts): -5.6
Expression Distribution
TNN Expression in NALM6 Cells: -5.6
