TPO

Entrez Summary: This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

An peroxidase
EGF CA

iodide peroxidase activity
thyroid hormone generation
thyroid hormone metabolic process
embryonic hemopoiesis
hydrogen peroxide catabolic process
peroxidase activity
hydrogen peroxide metabolic process
antibiotic catabolic process
hormone biosynthetic process
cofactor catabolic process
phenol-containing compound metabolic process
cellular oxidant detoxification
cellular detoxification
antibiotic metabolic process
reactive oxygen species metabolic process
detoxification
heme binding
drug catabolic process
cellular modified amino acid metabolic process
hormone metabolic process
cellular response to toxic substance
response to oxidative stress
embryonic organ development
cofactor metabolic process
organic hydroxy compound metabolic process
drug metabolic process
response to toxic substance
regulation of hormone levels
hemopoiesis
hematopoietic or lymphoid organ development
cell surface
immune system development
calcium ion binding
oxidation-reduction process
embryo development
integral component of plasma membrane
extracellular space
cellular catabolic process