TRADD

Gene Information

Official Symbol: TRADD
Official Name: TNFRSF1A associated via death domain
Aliases and Previous Symbols: N/A
Entrez ID: 8717
UniProt: Q15628
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A (By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12895
Expression level (log2 read counts): 3.09

Expression Distribution

Screen	Score
NMS-873 0.07μM R07 exp380	-2.05
Rapamycin 2μM R07 exp306	-1.76

Death
TRADD N

death domain binding
death-inducing signaling complex
death-inducing signaling complex assembly
positive regulation of hair follicle development
transmembrane receptor protein tyrosine kinase adaptor activity
positive regulation of hair cycle
regulation of hair follicle development
regulation of hair cycle
tumor necrosis factor receptor binding
extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of epidermis development
regulation of extrinsic apoptotic signaling pathway via death domain receptors
regulation of tumor necrosis factor-mediated signaling pathway
I-kappaB kinase/NF-kappaB signaling
positive regulation of NIK/NF-kappaB signaling
regulation of epidermis development
activation of cysteine-type endopeptidase activity involved in apoptotic process
kinase binding
extrinsic apoptotic signaling pathway
negative regulation of extrinsic apoptotic signaling pathway
protein heterooligomerization
regulation of NIK/NF-kappaB signaling
tumor necrosis factor-mediated signaling pathway
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of inflammatory response
positive regulation of cysteine-type endopeptidase activity
positive regulation of NF-kappaB transcription factor activity
regulation of extrinsic apoptotic signaling pathway
regulation of cytokine-mediated signaling pathway
positive regulation of endopeptidase activity
regulation of response to cytokine stimulus
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of peptidase activity
receptor complex
regulation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of apoptotic signaling pathway
membrane raft
regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to tumor necrosis factor