TRAF5

Entrez Summary: N/A
UniProt Summary: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. {ECO:0000269|PubMed:15121867}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
BN82002 4μM R07 exp340	-1.88
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.84

zf-TRAF
MATH

CD40 receptor complex
thioesterase binding
tumor necrosis factor receptor binding
cytoplasmic side of plasma membrane
positive regulation of NF-kappaB transcription factor activity
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of DNA-binding transcription factor activity
ubiquitin protein ligase binding
regulation of DNA-binding transcription factor activity
centrosome
protein-containing complex
zinc ion binding
apoptotic process
positive regulation of intracellular signal transduction
programmed cell death
identical protein binding
cell death
regulation of apoptotic process
regulation of programmed cell death
positive regulation of signal transduction
regulation of cell death
positive regulation of molecular function
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction