TRERF1

Entrez Summary: N/A
UniProt Summary: Binds DNA and activates transcription of CYP11A1. Interaction with CREBBP and EP300 results in a synergistic transcriptional activation of CYP11A1. {ECO:0000269|PubMed:11349124, ECO:0000269|PubMed:16371131}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Nutlin-3A 1.6μM R06 exp294	-1.8
ABT-702 5μM plus Deferoxamine 11μM R07 exp321	1.74
Ammonium tetrathiomolybdate 10μM R08 exp448	1.74
35°C R06 exp302	1.81
Azithromycin 100μM R08 exp452	1.9

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cholesterol catabolic process
sterol catabolic process
DNA binding, bending
steroid catabolic process
regulation of hormone biosynthetic process
histone deacetylase complex
regulation of hormone metabolic process
alcohol catabolic process
nuclear receptor transcription coactivator activity
organic hydroxy compound catabolic process
transcription coregulator activity
cholesterol metabolic process
steroid biosynthetic process
secondary alcohol metabolic process
sterol metabolic process
transcription factor complex
transcription regulatory region DNA binding
steroid metabolic process
lipid catabolic process
alcohol metabolic process
transcription factor binding
small molecule catabolic process
organic hydroxy compound metabolic process
organic cyclic compound catabolic process
regulation of hormone levels
lipid biosynthetic process
DNA-binding transcription factor activity
nucleolus
lipid metabolic process
organic cyclic compound biosynthetic process
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process
homeostatic process
positive regulation of RNA metabolic process
small molecule metabolic process
organic substance catabolic process
positive regulation of nucleobase-containing compound metabolic process
positive regulation of macromolecule biosynthetic process