TRIM13 [The Human Chemical-Genetic Interaction Map Project]

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======= TRIM13 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM13
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 13
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10206|10206]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O60858|O60858]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM13&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM13|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605661|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor (PubMed:22178386). Plays also a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation (PubMed:28087809). Participates as well in T-cell receptor- mediated NF-kappa-B activation (PubMed:25088585). In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B (PubMed:25152375). {ECO:0000269|PubMed:17314412, ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386, ECO:0000269|PubMed:25088585, ECO:0000269|PubMed:25152375, ECO:0000269|PubMed:28087809}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-C3HC4|
|zf-B box|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|negative regulation of viral release from host cell|
|endoplasmic reticulum mannose trimming|
|perinuclear endoplasmic reticulum|
|protein alpha-1,2-demannosylation|
|protein demannosylation|
|endoplasmic reticulum quality control compartment|
|negative regulation of viral transcription|
|protein deglycosylation|
|regulation of viral release from host cell|
|response to gamma radiation|
|regulation of viral transcription|
|protein autoubiquitination|
|positive regulation of macroautophagy|
|ubiquitin-dependent ERAD pathway|
|negative regulation of viral life cycle|
|ERAD pathway|
|negative regulation of viral process|
|positive regulation of autophagy|
|regulation of viral life cycle|
|response to ionizing radiation|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of macroautophagy|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of viral process|
|negative regulation of multi-organism process|
|regulation of symbiosis, encompassing mutualism through parasitism|
|ubiquitin protein ligase activity|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|ubiquitin-protein transferase activity|
|response to endoplasmic reticulum stress|
|positive regulation of DNA-binding transcription factor activity|
|negative regulation of locomotion|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|regulation of autophagy|
|proteasomal protein catabolic process|
|positive regulation of cellular catabolic process|
|glycoprotein metabolic process|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|response to radiation|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|positive regulation of cell death|
|innate immune response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|regulation of cellular catabolic process|
|zinc ion binding|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|defense response to other organism|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|response to organonitrogen compound|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|response to abiotic stimulus|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|positive regulation of signal transduction|
|regulation of cell death|
|cellular response to stress|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-1.86|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16884
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM13 Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>