TRIM13

Gene Information

Official Symbol: TRIM13
Official Name: tripartite motif containing 13
Aliases and Previous Symbols: N/A
Entrez ID: 10206
UniProt: O60858
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Endoplasmic reticulum (ER) membrane anchored E3 ligase involved in the retrotranslocation and turnover of membrane and secretory proteins from the ER through a set of processes named ER-associated degradation (ERAD). This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins. Enhances ionizing radiation-induced p53/TP53 stability and apoptosis via ubiquitinating MDM2 and AKT1 and decreasing AKT1 kinase activity through MDM2 and AKT1 proteasomal degradation. Regulates ER stress-induced autophagy, and may act as a tumor suppressor (PubMed:22178386). Plays also a role in innate immune response by stimulating NF-kappa-B activity in the TLR2 signaling pathway. Ubiquitinates TRAF6 via the 'Lys-29'-linked polyubiquitination chain resulting in NF-kappa-B activation (PubMed:28087809). Participates as well in T-cell receptor- mediated NF-kappa-B activation (PubMed:25088585). In the presence of TNF, modulates the IKK complex by regulating IKBKG/NEMO ubiquitination leading to the repression of NF-kappa-B (PubMed:25152375). {ECO:0000269|PubMed:17314412, ECO:0000269|PubMed:21333377, ECO:0000269|PubMed:22178386, ECO:0000269|PubMed:25088585, ECO:0000269|PubMed:25152375, ECO:0000269|PubMed:28087809}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16884
Expression level (log2 read counts): 5.99

Expression Distribution

Screen	Score
Rapamycin 2μM R07 exp306	-2
Asunaprenir 3μM R07 exp336	-1.86
Palbociclib 1μM R07 exp382	-1.81

zf-C3HC4
zf-B box

negative regulation of viral release from host cell
endoplasmic reticulum mannose trimming
perinuclear endoplasmic reticulum
protein alpha-1,2-demannosylation
protein demannosylation
endoplasmic reticulum quality control compartment
negative regulation of viral transcription
protein deglycosylation
regulation of viral release from host cell
response to gamma radiation
regulation of viral transcription
protein autoubiquitination
positive regulation of macroautophagy
ubiquitin-dependent ERAD pathway
negative regulation of viral life cycle
ERAD pathway
negative regulation of viral process
positive regulation of autophagy
regulation of viral life cycle
response to ionizing radiation
positive regulation of NF-kappaB transcription factor activity
regulation of macroautophagy
positive regulation of I-kappaB kinase/NF-kappaB signaling
regulation of viral process
negative regulation of multi-organism process
regulation of symbiosis, encompassing mutualism through parasitism
ubiquitin protein ligase activity
regulation of I-kappaB kinase/NF-kappaB signaling
ubiquitin-protein transferase activity
response to endoplasmic reticulum stress
positive regulation of DNA-binding transcription factor activity
negative regulation of locomotion
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of autophagy
proteasomal protein catabolic process
positive regulation of cellular catabolic process
glycoprotein metabolic process
regulation of DNA-binding transcription factor activity
positive regulation of catabolic process
response to radiation