TRIM32 [The Human Chemical-Genetic Interaction Map Project]

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======= TRIM32 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TRIM32
  * **<color #00a2e8>Official Name</color>**: tripartite motif containing 32
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=22954|22954]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13049|Q13049]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TRIM32&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TRIM32|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602290|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo. {ECO:0000269|PubMed:19349376, ECO:0000269|PubMed:22500027}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NHL|
|zf-C3HC4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of chemokine (C-C motif) ligand 20 production|
|positive regulation of interleukin-17-mediated signaling pathway|
|regulation of interleukin-17-mediated signaling pathway|
|actin ubiquitination|
|regulation of chemokine (C-C motif) ligand 20 production|
|striated muscle myosin thick filament|
|actin modification|
|positive regulation of tumor necrosis factor-mediated signaling pathway|
|Tat protein binding|
|negative regulation of viral release from host cell|
|muscle cell cellular homeostasis|
|translation initiation factor binding|
|myosin binding|
|negative regulation of viral transcription|
|negative regulation of fibroblast proliferation|
|negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|regulation of viral release from host cell|
|regulation of intrinsic apoptotic signaling pathway in response to DNA damage|
|positive regulation of cytokine-mediated signaling pathway|
|protein K48-linked ubiquitination|
|protein self-association|
|positive regulation of chemokine production|
|positive regulation of response to cytokine stimulus|
|regulation of tumor necrosis factor-mediated signaling pathway|
|positive regulation of striated muscle cell differentiation|
|regulation of viral transcription|
|regulation of chemokine production|
|negative regulation of response to DNA damage stimulus|
|ubiquitin binding|
|regulation of fibroblast proliferation|
|negative regulation of viral life cycle|
|positive regulation of muscle cell differentiation|
|negative regulation of intrinsic apoptotic signaling pathway|
|negative regulation of viral process|
|regulation of striated muscle cell differentiation|
|fat cell differentiation|
|regulation of type I interferon production|
|response to UV|
|regulation of viral life cycle|
|positive regulation of NF-kappaB transcription factor activity|
|regulation of muscle cell differentiation|
|regulation of intrinsic apoptotic signaling pathway|
|regulation of cytokine-mediated signaling pathway|
|positive regulation of cell growth|
|regulation of response to cytokine stimulus|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|tissue homeostasis|
|regulation of viral process|
|negative regulation of multi-organism process|
|positive regulation of protein catabolic process|
|regulation of response to DNA damage stimulus|
|regulation of symbiosis, encompassing mutualism through parasitism|
|ubiquitin protein ligase activity|
|negative regulation of apoptotic signaling pathway|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|ubiquitin-protein transferase activity|
|positive regulation of growth|
|positive regulation of DNA-binding transcription factor activity|
|response to tumor necrosis factor|
|transcription coactivator activity|
|protein polyubiquitination|
|response to light stimulus|
|negative regulation of locomotion|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|positive regulation of proteolysis|
|positive regulation of neuron differentiation|
|positive regulation of cell cycle|
|regulation of protein catabolic process|
|regulation of apoptotic signaling pathway|
|axon development|
|regulation of cell growth|
|regulation of DNA-binding transcription factor activity|
|positive regulation of catabolic process|
|response to radiation|
|positive regulation of cytokine production|
|positive regulation of neurogenesis|
|actin cytoskeleton organization|
|positive regulation of cell migration|
|negative regulation of intracellular signal transduction|
|positive regulation of cell motility|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|positive regulation of nervous system development|
|positive regulation of cellular component movement|
|positive regulation of cell development|
|modification-dependent macromolecule catabolic process|
|positive regulation of locomotion|
|actin filament-based process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|regulation of neuron differentiation|
|neuron projection development|
|regulation of growth|
|negative regulation of cell population proliferation|
|protein catabolic process|
|protein ubiquitination|
|regulation of cytokine production|
|regulation of proteolysis|
|regulation of cellular response to stress|
|innate immune response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|neuron development|
|regulation of neurogenesis|
|zinc ion binding|
|regulation of cell migration|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|regulation of cell motility|
|regulation of nervous system development|
|regulation of cell development|
|defense response to other organism|
|positive regulation of cell differentiation|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of cellular component movement|
|regulation of catabolic process|
|negative regulation of cell death|
|neuron differentiation|
|positive regulation of intracellular signal transduction|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|response to cytokine|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|response to abiotic stimulus|
|cell projection organization|
|regulation of cell cycle|
|negative regulation of signal transduction|
|proteolysis|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|RNA binding|
|regulation of response to stress|
|generation of neurons|
|regulation of apoptotic process|
|regulation of programmed cell death|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|immune response|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp129|Isonicotinamide 500μM R03 exp129]]|-1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10924
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.89 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TRIM32 Expression in NALM6 Cells: 4.89'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>