TRIM32
Gene Information
- Official Symbol: TRIM32
- Official Name: tripartite motif containing 32
- Aliases and Previous Symbols: N/A
- Entrez ID: 22954
- UniProt: Q13049
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008].
- UniProt Summary: Has an E3 ubiquitin ligase activity. Ubiquitinates DTNBP1 (dysbindin) and promotes its degradation. May ubiquitinate BBS2. May play a significant role in mediating the biological activity of the HIV-1 Tat protein in vivo. Binds specifically to the activation domain of HIV-1 Tat and can also interact with the HIV-2 and EIAV Tat proteins in vivo. {ECO:0000269|PubMed:19349376, ECO:0000269|PubMed:22500027}.
Pfam Domains GO Terms
Pfam Domains
| NHL |
| zf-C3HC4 |
GO Terms
| positive regulation of chemokine (C-C motif) ligand 20 production |
| positive regulation of interleukin-17-mediated signaling pathway |
| regulation of interleukin-17-mediated signaling pathway |
| actin ubiquitination |
| regulation of chemokine (C-C motif) ligand 20 production |
| striated muscle myosin thick filament |
| actin modification |
| positive regulation of tumor necrosis factor-mediated signaling pathway |
| Tat protein binding |
| negative regulation of viral release from host cell |
| muscle cell cellular homeostasis |
| translation initiation factor binding |
| myosin binding |
| negative regulation of viral transcription |
| negative regulation of fibroblast proliferation |
| negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| regulation of viral release from host cell |
| regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| positive regulation of cytokine-mediated signaling pathway |
| protein K48-linked ubiquitination |
| protein self-association |
| positive regulation of chemokine production |
| positive regulation of response to cytokine stimulus |
| regulation of tumor necrosis factor-mediated signaling pathway |
| positive regulation of striated muscle cell differentiation |
| regulation of viral transcription |
| regulation of chemokine production |
| negative regulation of response to DNA damage stimulus |
| ubiquitin binding |
| regulation of fibroblast proliferation |
| negative regulation of viral life cycle |
| positive regulation of muscle cell differentiation |
| negative regulation of intrinsic apoptotic signaling pathway |
| negative regulation of viral process |
| regulation of striated muscle cell differentiation |
| fat cell differentiation |
| regulation of type I interferon production |
| response to UV |
| regulation of viral life cycle |
| positive regulation of NF-kappaB transcription factor activity |
| regulation of muscle cell differentiation |
| regulation of intrinsic apoptotic signaling pathway |
| regulation of cytokine-mediated signaling pathway |
| positive regulation of cell growth |
| regulation of response to cytokine stimulus |
| positive regulation of I-kappaB kinase/NF-kappaB signaling |
| tissue homeostasis |
| regulation of viral process |
| negative regulation of multi-organism process |
| positive regulation of protein catabolic process |
| regulation of response to DNA damage stimulus |
| regulation of symbiosis, encompassing mutualism through parasitism |
| ubiquitin protein ligase activity |
| negative regulation of apoptotic signaling pathway |
| regulation of I-kappaB kinase/NF-kappaB signaling |
| ubiquitin-protein transferase activity |
| positive regulation of growth |
| positive regulation of DNA-binding transcription factor activity |
| response to tumor necrosis factor |
| transcription coactivator activity |
| protein polyubiquitination |
| response to light stimulus |
| negative regulation of locomotion |
| multicellular organismal homeostasis |
| anatomical structure homeostasis |
| positive regulation of proteolysis |
| positive regulation of neuron differentiation |
| positive regulation of cell cycle |
| regulation of protein catabolic process |
| regulation of apoptotic signaling pathway |
| axon development |
| regulation of cell growth |
| regulation of DNA-binding transcription factor activity |
| positive regulation of catabolic process |
| response to radiation |
| positive regulation of cytokine production |
| positive regulation of neurogenesis |
| actin cytoskeleton organization |
| positive regulation of cell migration |
| negative regulation of intracellular signal transduction |
| positive regulation of cell motility |
| ubiquitin-dependent protein catabolic process |
| modification-dependent protein catabolic process |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| positive regulation of cell development |
| modification-dependent macromolecule catabolic process |
| positive regulation of locomotion |
| actin filament-based process |
| proteolysis involved in cellular protein catabolic process |
| cellular protein catabolic process |
| regulation of neuron differentiation |
| neuron projection development |
| regulation of growth |
| negative regulation of cell population proliferation |
| protein catabolic process |
| protein ubiquitination |
| regulation of cytokine production |
| regulation of proteolysis |
| regulation of cellular response to stress |
| innate immune response |
| protein modification by small protein conjugation |
| regulation of multi-organism process |
| neuron development |
| regulation of neurogenesis |
| zinc ion binding |
| regulation of cell migration |
| negative regulation of apoptotic process |
| cellular homeostasis |
| negative regulation of programmed cell death |
| cellular macromolecule catabolic process |
| regulation of cell motility |
| regulation of nervous system development |
| regulation of cell development |
| defense response to other organism |
| positive regulation of cell differentiation |
| regulation of locomotion |
| protein modification by small protein conjugation or removal |
| regulation of cellular component movement |
| regulation of catabolic process |
| negative regulation of cell death |
| neuron differentiation |
| positive regulation of intracellular signal transduction |
| macromolecule catabolic process |
| organonitrogen compound catabolic process |
| identical protein binding |
| response to cytokine |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| response to abiotic stimulus |
| cell projection organization |
| regulation of cell cycle |
| negative regulation of signal transduction |
| proteolysis |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| RNA binding |
| regulation of response to stress |
| generation of neurons |
| regulation of apoptotic process |
| regulation of programmed cell death |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| organic substance catabolic process |
| positive regulation of molecular function |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Isonicotinamide 500μM R03 exp129 | -1.75 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10924
- Expression level (log2 read counts): 4.89
Expression Distribution
TRIM32 Expression in NALM6 Cells: 4.89
