TRIM39

Entrez Summary: N/A
UniProt Summary: E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. {ECO:0000269|PubMed:19100260, ECO:0000269|PubMed:22529100}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

negative regulation of ubiquitin-dependent protein catabolic process
transferase activity
negative regulation of proteolysis involved in cellular protein catabolic process
negative regulation of cellular protein catabolic process
negative regulation of protein catabolic process
regulation of ubiquitin-dependent protein catabolic process
positive regulation of apoptotic signaling pathway
regulation of proteolysis involved in cellular protein catabolic process
regulation of cellular protein catabolic process
negative regulation of cellular catabolic process
negative regulation of catabolic process
negative regulation of proteolysis
regulation of protein catabolic process
regulation of apoptotic signaling pathway
positive regulation of apoptotic process
positive regulation of programmed cell death
protein ubiquitination
positive regulation of cell death
regulation of proteolysis
protein modification by small protein conjugation
regulation of cellular catabolic process
zinc ion binding
apoptotic process
protein modification by small protein conjugation or removal
regulation of catabolic process
negative regulation of cellular protein metabolic process
programmed cell death
identical protein binding
cell death
negative regulation of protein metabolic process
mitochondrion
regulation of apoptotic process
regulation of programmed cell death
positive regulation of signal transduction
regulation of cell death
positive regulation of cell communication
positive regulation of signaling