TSHR

Gene Information

Official Symbol: TSHR
Official Name: thyroid stimulating hormone receptor
Aliases and Previous Symbols: N/A
Entrez ID: 7253
UniProt: P16473
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a membrane protein and a major controller of thyroid cell metabolism. The encoded protein is a receptor for thyrothropin and thyrostimulin, and its activity is mediated by adenylate cyclase. Defects in this gene are a cause of several types of hyperthyroidism. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9766
Expression level (log2 read counts): -1.52

Expression Distribution

cellular response to thyrotropin-releasing hormone
cellular response to glycoprotein
thyroid-stimulating hormone receptor activity
response to thyrotropin-releasing hormone
thyroid-stimulating hormone signaling pathway
response to glycoprotein
G protein-coupled peptide receptor activity
activation of adenylate cyclase activity
positive regulation of cold-induced thermogenesis
adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of cold-induced thermogenesis
cAMP-mediated signaling
hormone-mediated signaling pathway
cyclic-nucleotide-mediated signaling
basolateral plasma membrane
receptor complex
signaling receptor activity
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
protein-containing complex binding
cellular response to peptide hormone stimulus
cellular response to peptide
second-messenger-mediated signaling
response to peptide hormone
response to peptide
cellular response to organonitrogen compound
cellular response to hormone stimulus
cell surface
cellular response to nitrogen compound
response to hormone
positive regulation of cell population proliferation
response to organonitrogen compound
cellular response to oxygen-containing compound
response to nitrogen compound
cell-cell signaling
cellular response to endogenous stimulus
G protein-coupled receptor signaling pathway
integral component of plasma membrane
response to endogenous stimulus
response to oxygen-containing compound