TSPYL2 [The Human Chemical-Genetic Interaction Map Project]

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======= TSPYL2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TSPYL2
  * **<color #00a2e8>Official Name</color>**: TSPY like 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=64061|64061]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9H2G4|Q9H2G4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TSPYL2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TSPYL2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300564|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269|PubMed:11395479, ECO:0000269|PubMed:17317670}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rDNA binding|
|negative regulation of DNA replication|
|IRE1-mediated unfolded protein response|
|endoplasmic reticulum unfolded protein response|
|regulation of DNA replication|
|nucleosome assembly|
|cellular response to unfolded protein|
|chromatin assembly|
|cellular response to topologically incorrect protein|
|chromatin assembly or disassembly|
|nucleosome organization|
|response to unfolded protein|
|DNA packaging|
|negative regulation of cell growth|
|response to topologically incorrect protein|
|protein-DNA complex assembly|
|protein-DNA complex subunit organization|
|negative regulation of growth|
|response to endoplasmic reticulum stress|
|DNA conformation change|
|regulation of cell growth|
|negative regulation of cell cycle|
|regulation of growth|
|chromatin organization|
|regulation of protein kinase activity|
|cellular protein-containing complex assembly|
|nucleolus|
|regulation of kinase activity|
|regulation of transferase activity|
|chromosome organization|
|regulation of cell cycle|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of phosphorylation|
|cellular response to stress|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-2.2|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-1.85|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-1.8|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|1.85|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/683
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/25|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/14|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5245
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.9 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TSPYL2 Expression in NALM6 Cells: 4.9'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>