TSPYL2

Entrez Summary: This gene encodes a member of the testis-specific protein Y-encoded, TSPY-like/SET/nucleosome assembly protein-1 superfamily. The encoded protein is localized to the nucleolus where it functions in chromatin remodeling and as an inhibitor of cell-cycle progression. This protein may play a role in the suppression of tumor growth. [provided by RefSeq, Sep 2009].
UniProt Summary: Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269|PubMed:11395479, ECO:0000269|PubMed:17317670}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/683

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/25
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/14
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

rDNA binding
negative regulation of DNA replication
IRE1-mediated unfolded protein response
endoplasmic reticulum unfolded protein response
regulation of DNA replication
nucleosome assembly
cellular response to unfolded protein
chromatin assembly
cellular response to topologically incorrect protein
chromatin assembly or disassembly
nucleosome organization
response to unfolded protein
DNA packaging
negative regulation of cell growth
response to topologically incorrect protein
protein-DNA complex assembly
protein-DNA complex subunit organization
negative regulation of growth
response to endoplasmic reticulum stress
DNA conformation change
regulation of cell growth
negative regulation of cell cycle
regulation of growth
chromatin organization
regulation of protein kinase activity
cellular protein-containing complex assembly
nucleolus
regulation of kinase activity
regulation of transferase activity
chromosome organization
regulation of cell cycle
cell cycle
negative regulation of cellular macromolecule biosynthetic process
regulation of protein phosphorylation
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
protein-containing complex assembly
regulation of phosphorylation
cellular response to stress