TTBK1 [The Human Chemical-Genetic Interaction Map Project]

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======= TTBK1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TTBK1
  * **<color #00a2e8>Official Name</color>**: tau tubulin kinase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84630|84630]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5TCY1|Q5TCY1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TTBK1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TTBK1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/619415|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: This gene belongs to the casein kinase 1 superfamily. The encoded protein is a neuron-specific, serine/threonine and tyrosine kinase, which regulates phosphorylation of tau, a protein that associates with microtubule assemblies and stabilizes them. Genetic variants in this gene are associated with Alzheimer's disease. [provided by RefSeq, Jul 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. {ECO:0000269|PubMed:16923168}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Pkinase Tyr|
|Pkinase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of astrocyte activation|
|regulation of astrocyte activation|
|positive regulation of microglial cell activation|
|positive regulation of astrocyte differentiation|
|positive regulation of neuroinflammatory response|
|regulation of microglial cell activation|
|tau-protein kinase activity|
|positive regulation of macrophage activation|
|regulation of astrocyte differentiation|
|regulation of neuroinflammatory response|
|microtubule associated complex|
|positive regulation of cyclin-dependent protein kinase activity|
|positive regulation of glial cell differentiation|
|substantia nigra development|
|tau protein binding|
|regulation of macrophage activation|
|neural nucleus development|
|positive regulation of gliogenesis|
|regulation of glial cell differentiation|
|peptidyl-threonine phosphorylation|
|midbrain development|
|peptidyl-threonine modification|
|regulation of cyclin-dependent protein kinase activity|
|negative regulation of protein binding|
|regulation of gliogenesis|
|positive regulation of protein polymerization|
|positive regulation of inflammatory response|
|peptidyl-tyrosine phosphorylation|
|peptidyl-tyrosine modification|
|positive regulation of cysteine-type endopeptidase activity|
|negative regulation of binding|
|positive regulation of endopeptidase activity|
|peptidyl-serine phosphorylation|
|positive regulation of peptidase activity|
|peptidyl-serine modification|
|regulation of protein binding|
|regulation of protein polymerization|
|regulation of cysteine-type endopeptidase activity|
|positive regulation of protein complex assembly|
|learning or memory|
|cognition|
|regulation of inflammatory response|
|positive regulation of proteolysis|
|protein serine/threonine kinase activity|
|neuronal cell body|
|regulation of binding|
|positive regulation of leukocyte activation|
|positive regulation of cell activation|
|regulation of endopeptidase activity|
|regulation of peptidase activity|
|regulation of protein complex assembly|
|positive regulation of neurogenesis|
|positive regulation of defense response|
|positive regulation of cellular component biogenesis|
|positive regulation of protein kinase activity|
|positive regulation of nervous system development|
|positive regulation of cell development|
|behavior|
|positive regulation of kinase activity|
|positive regulation of response to external stimulus|
|regulation of leukocyte activation|
|regulation of cell activation|
|positive regulation of transferase activity|
|perinuclear region of cytoplasm|
|regulation of proteolysis|
|brain development|
|regulation of defense response|
|positive regulation of hydrolase activity|
|head development|
|regulation of protein kinase activity|
|regulation of neurogenesis|
|regulation of kinase activity|
|peptidyl-amino acid modification|
|regulation of nervous system development|
|regulation of cell development|
|regulation of cellular component biogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|regulation of transferase activity|
|central nervous system development|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|negative regulation of molecular function|
|positive regulation of immune system process|
|regulation of cell cycle|
|positive regulation of cellular component organization|
|positive regulation of protein modification process|
|regulation of hydrolase activity|
|phosphorylation|
|positive regulation of developmental process|
|nervous system process|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|generation of neurons|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|regulation of immune system process|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|regulation of protein modification process|
|system process|
|positive regulation of gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|-1.9|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.432|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2396
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.26 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TTBK1 Expression in NALM6 Cells: -0.26'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>