TTBK1

Gene Information

Official Symbol: TTBK1
Official Name: tau tubulin kinase 1
Aliases and Previous Symbols: N/A
Entrez ID: 84630
UniProt: Q5TCY1
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene belongs to the casein kinase 1 superfamily. The encoded protein is a neuron-specific, serine/threonine and tyrosine kinase, which regulates phosphorylation of tau, a protein that associates with microtubule assemblies and stabilizes them. Genetic variants in this gene are associated with Alzheimer's disease. [provided by RefSeq, Jul 2016].
UniProt Summary: Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. {ECO:0000269|PubMed:16923168}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 2396
Expression level (log2 read counts): -0.26

Expression Distribution

Pkinase Tyr
Pkinase

positive regulation of astrocyte activation
regulation of astrocyte activation
positive regulation of microglial cell activation
positive regulation of astrocyte differentiation
positive regulation of neuroinflammatory response
regulation of microglial cell activation
tau-protein kinase activity
positive regulation of macrophage activation
regulation of astrocyte differentiation
regulation of neuroinflammatory response
microtubule associated complex
positive regulation of cyclin-dependent protein kinase activity
positive regulation of glial cell differentiation
substantia nigra development
tau protein binding
regulation of macrophage activation
neural nucleus development
positive regulation of gliogenesis
regulation of glial cell differentiation
peptidyl-threonine phosphorylation
midbrain development
peptidyl-threonine modification
regulation of cyclin-dependent protein kinase activity
negative regulation of protein binding
regulation of gliogenesis
positive regulation of protein polymerization
positive regulation of inflammatory response
peptidyl-tyrosine phosphorylation
peptidyl-tyrosine modification
positive regulation of cysteine-type endopeptidase activity
negative regulation of binding
positive regulation of endopeptidase activity
peptidyl-serine phosphorylation
positive regulation of peptidase activity
peptidyl-serine modification
regulation of protein binding
regulation of protein polymerization
regulation of cysteine-type endopeptidase activity
positive regulation of protein complex assembly
learning or memory