TTC17

Entrez Summary: N/A
UniProt Summary: Plays a role in primary ciliogenesis by modulating actin polymerization. {ECO:0000269|PubMed:24475127}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Pimelic-diphenylamide-106 5μM R00 exp28	-1.87
Nocodazole 0.1μM R03 exp94	-1.76
Heregulin-B 44ng/ml R08 exp486	-1.73
L-BMAA 500 to 750μM on day4 R04 exp185	1.76
Sulforaphane 9μM R08 exp526 no dilution day6	1.77

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

actin filament polymerization
actin polymerization or depolymerization
protein polymerization
actin cytoskeleton
actin filament organization
cilium organization
supramolecular fiber organization
actin cytoskeleton organization
actin filament-based process
cellular protein-containing complex assembly
cytoskeleton organization
plasma membrane bounded cell projection organization
cell projection organization
protein-containing complex assembly
protein-containing complex subunit organization