TULP3 [The Human Chemical-Genetic Interaction Map Project]

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======= TULP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TULP3
  * **<color #00a2e8>Official Name</color>**: TUB like protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7289|7289]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75386|O75386]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TULP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TULP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604730|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein- coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT- A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis. {ECO:0000269|PubMed:11375483, ECO:0000269|PubMed:20889716}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tub|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|bronchus morphogenesis|
|9+0 non-motile cilium|
|intraciliary transport particle A binding|
|negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning|
|negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|
|embryonic neurocranium morphogenesis|
|smoothened signaling pathway involved in dorsal/ventral neural tube patterning|
|regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning|
|bronchus development|
|ganglion development|
|dorsal/ventral neural tube patterning|
|spinal cord dorsal/ventral patterning|
|spinal cord patterning|
|negative regulation of embryonic development|
|negative regulation of smoothened signaling pathway|
|neural tube patterning|
|ciliary base|
|embryonic camera-type eye development|
|embryonic cranial skeleton morphogenesis|
|protein localization to cilium|
|embryonic digit morphogenesis|
|cranial skeletal system development|
|G protein-coupled receptor binding|
|smoothened signaling pathway|
|phosphatidylinositol-4,5-bisphosphate binding|
|regulation of smoothened signaling pathway|
|dorsal/ventral pattern formation|
|phosphatidylinositol binding|
|neural tube closure|
|tube closure|
|embryonic skeletal system morphogenesis|
|primary neural tube formation|
|axoneme|
|neural tube formation|
|spinal cord development|
|embryonic epithelial tube formation|
|embryonic limb morphogenesis|
|embryonic appendage morphogenesis|
|embryonic skeletal system development|
|regulation of embryonic development|
|epithelial tube formation|
|regulation of G protein-coupled receptor signaling pathway|
|morphogenesis of embryonic epithelium|
|tube formation|
|limb morphogenesis|
|appendage morphogenesis|
|neural tube development|
|respiratory tube development|
|central nervous system neuron differentiation|
|appendage development|
|limb development|
|respiratory system development|
|cilium|
|bone development|
|anterior/posterior pattern specification|
|skeletal system morphogenesis|
|protein-containing complex binding|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|negative regulation of nervous system development|
|camera-type eye development|
|regionalization|
|enzyme binding|
|eye development|
|visual system development|
|sensory system development|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|skeletal system development|
|sensory organ development|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|protein localization to organelle|
|brain development|
|head development|
|tube development|
|nucleolus|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|central nervous system development|
|neuron differentiation|
|epithelium development|
|negative regulation of multicellular organismal process|
|negative regulation of signal transduction|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|generation of neurons|
|cellular protein localization|
|cellular macromolecule localization|
|negative regulation of response to stimulus|
|neurogenesis|
|tissue development|
|extracellular region|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.74|
|[[:results:exp301|VER-155008 3.9μM R06 exp301]]|2.13|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15776
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.3 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TULP3 Expression in NALM6 Cells: 4.3'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>